Dosing

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happy young men and women gathered around a table while eating food

A once-daily oral tablet for patients with cGVHD1

Dose modifications for adverse reactions are related to the
grade of cGVHD severity1

Recommended dose modifications for REZUROCK for adverse reactions

table of dose modifications for REZUROCK, including hepatotoxicity and other adverse reactions
table of dose modifications for REZUROCK, including hepatotoxicity and other adverse reactions

Please see the full Prescribing Information for additional guidance for other populations

Dose modifications for patients with renal or hepatic impairment1

Renal impairment

Patients with mild to moderate renal impairment

  • No clinically significant differences in REZUROCK pharmacokinetics observed

Patients with severe renal impairment

  • No data are available for patients with severe renal impairment

Hepatic impairment

Patients with hepatic impairment

  • No data are available for patients with hepatic impairment

Use in specific populations1

Pregnancy

  • REZUROCK can cause fetal harm when administered to pregnant women
  • Advise pregnant women of the potential risk to the fetus. Advise women of reproductive potential, and their male partners, to use effective contraception during treatment with REZUROCK and for at least 1 week after the last dose
    of REZUROCK

Pediatric use

  • The safety and effectiveness of REZUROCK in pediatric patients aged <12 years have not been established

Geriatric use

  • Of the 186 patients with cGVHD in clinical studies of REZUROCK, 26% were aged ≥65 years. No clinically meaningful differences in safety or effectiveness of REZUROCK were observed in comparison to younger patients

Drug interactions1

Please see the full Prescribing Information for additional information on drug interactions.

Storage1

Store REZUROCK at room temperature, ranging from 68 °F to 77 °F (20 °C-25 °C); excursions are permitted from 59 °F to 86 °F (15 °C-30 °C).

Dispense REZUROCK to patients in its original container only. Store REZUROCK in its original container to protect from moisture. Replace the cap securely each time after opening. Do not discard desiccant.

Help your patients get started on REZUROCK.

LEARN ABOUT KADMON ASSISTTM

ALT, alanine aminotransferase; AST, aspartate aminotransferase; cGVHD, chronic graft-versus-host disease; CYP3A, cytochrome P450 3A; MOA, mechanism of action; ULN, upper limit of normal.

Reference: 1. REZUROCK. Package insert. Kadmon Pharmaceuticals, LLC; 2021.