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Challenges of Disease Progression

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Patients routinely require multiple lines of systemic therapy to address the ongoing burden of cGVHD1

A prospective, multicenter, observational study, which included 250 adult patients who underwent an alloHCT and subsequently received treatment for cGVHD, demonstrated that1

  • Patients received a median of 3 lines of systemic therapy, and the median time to permanent discontinuation of IST was 69 months
  • Progressive disease or lack of improvement was the reason 86% of patients required the initiation of new treatments, indicating a lack of cGVHD control with previous lines of systemic therapy
  • More than half of patients who discontinued IST at least 1 time had to restart IST within a median of 3.4 months
  • Of the patients attempting a first-time discontinuation of IST, 23% did so only after 3 lines of systemic therapy
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of patients with cGVHD require additional treatment following initial therapies.2

Patients with cGVHD often have poor QOL, regardless of disease severity3

The clinically significant reductions in QOL that can occur with all severity grades (mild through severe) of cGVHD may be underestimated by physicians.3

The burden of cGVHD is multifaceted, with patients experiencing poor QOL and progressive disability3,4,a

circular icon with bar graph showing decreasing quality-of-life (QOL) value

QOL scores across all domains are lower in patients with greater cGVHD severity.3

  • Even patients with mild cGVHD symptoms in the lungs, GI tract and joints/fascia
    have clinically meaningful deterioration in physical QOL

aIn a national cross-sectional questionnaire study conducted in Japan, VAS scores were evaluated using 1140 pairs of patient and physician questionnaires. The data were collected from recipients of alloHCT for hematologic disease between 1995 and 2009. The VAS was used to assess the physical, psychological and social QOL of long-term survivors of alloHCT (median time post alloHCT of 7 years) who had various degrees of cGVHD severity.3



evaluated in a real-world demographic of patients with cGVHD.5

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alloHCT, allogeneic hematopoietic cell transplant; cGVHD, chronic graft-versus-host disease; GI, gastrointestinal; HLA, human leukocyte antigen; IST, immunosuppressive therapy; MDS, myelodysplastic syndrome; MOA, mechanism of action; QOL, quality of life; VAS, visual analog scale.

References: 1. Lee SJ, Nguyen TD, Onstad L, et al. Success of immunosuppressive treatments in patients with chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2018;24(3):555-562. doi:10.1016/j.bbmt.2017.10.042 2. Bachier CR, Aggarwal SK, Hennegan K, Milgroom A, Rotto M. Epidemiology and real-world treatment of chronic graft-versus-host disease post allogeneic hematopoietic cell transplantation: a US claims analysis. Abstract presented at: The 62nd American Society of Hematology Conference. December 7, 2019; Orlando, FL. 3. Kurosawa S, Oshima K, Yamaguchi T, et al. Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2017;23(10):1749-1758. doi:10.1016/j.bbmt.2017.06.011 4. Hamilton BK, Storer BE, Wood WA, et al. Disability related to chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2020;26(4):772-777. doi:10.1016/j.bbmt.2019.10.019 5. REZUROCK. Package insert. Kadmon Pharmaceuticals, LLC; 2021.

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